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KMID : 0358920080350040671
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Journal of the Korean Academy of Pedodontics
2008 Volume.35 No. 4 p.671 ~ p.676
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The Relationship between the Salivary IgA against AgI/II of S. mutans and Dental Caries Experience among Children and Adults
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Lim Su-Min
Kim Jae-Gon
Baik Byeong-Ju
Yang Yeon-Mi
Kim Su-Kyung
Lee Kyung-Yol
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Abstract
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AgI/II of Streptococcus mutans(S. mutans) is an important virulence factor that contributes to the pathogenesis of S. mutans-induced dental caries. In oral cavity, salivary IgA antibodies act as safeguards against enormous challenges from oral bacteria. IgA antibodies inhibit adherence of cariogenic microorganisms to hard surfaces. Analysis of salivary IgA against AgI/II can be very useful diagnostic and powerful communication tools to the dental caries The purpose of this study was to investigate correlation between salivary AgI/II specific IgA and incidence of dental caries among children and young adults. Subjects consisted of 28 children and 18 adults. They were assigned to four groups : Group I deft index 3), Group II(deft index 4), Group III(DMFT index 3), Group IV(DMFT index 4) and they was divided two groups into caries resistant group and caries susceptible group. The study group were examined caries activity and their salivary IgA was evaluated by enzyme-linked immunosorbent assay. The results are as follows : 1. There was a positive correlation between the number of S. mutans and caries activity. 2. The titer of salivary IgA against the AgI/II was significantly higher in caries resistant group than caries susceptible group(p<0.01). 3. The titer of salivary IgA against the AgI/II in Group III was significantly higher than Group II(p<0.05).
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KEYWORD
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Dental Caries, AgI/II, Salivary IgA, ELISA
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